KPV

KPV is a naturally derived tripeptide (Lys-Pro-Val) corresponding to the C-terminal α-MSH fragment (residues 11–13). It is utilized in in vitro biochemical research to investigate NF-κB signaling attenuation, pro-inflammatory cytokine (TNF-α, IL-6) modulation, and mechanisms of α-MSH-mediated anti-inflammatory activity in epithelial cell models.