Semaglutide

Semaglutide is a synthetic 31-amino-acid analogue of native glucagon-like peptide-1 (GLP-1), modified with a C18 fatty acid side chain and an α-aminoisobutyric acid (Aib) substitution at position 2 for enzymatic stability and albumin binding. It is utilized in in vitro biochemical research to investigate GLP-1 receptor activation, pancreatic β-cell insulinotropic signaling, and pathways related to appetite regulation and gastric emptying.