Tirzepatide

Tirzepatide is a synthetic 39-amino-acid dual-agonist peptide targeting the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, conjugated with a C20 fatty diacid moiety for albumin binding and extended half-life. It is utilized in in vitro biochemical research to investigate incretin receptor cross-signaling, β-cell insulinotropic response, and pathways influencing glucose homeostasis and body composition.